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CRP and ESR? Options
Ailsa-H
#1 Posted : Tuesday, February 15, 2011 7:08:49 PM Quote
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I know they both measure inflammation but how do they differ? I was delighted to be told today that my CRP has halved to 14 after 3 Enbrel injections, but then confused that the ESR had doubled to 98! Is it working yet? I'm trying to work out what is going on!
suzanne_p
#2 Posted : Tuesday, February 15, 2011 7:17:35 PM Quote
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hi Ailsa,

would love to know the answer to this too,

i remember LynW explaining it clearly when i was a Newbie, so am sure she'll oblige once she see's this as will others.

but i am sure your CRP is relatively good ... as after i have had a Depo injection mine usually goes down to about 5 and the pain's are more or less gone.

but my ESR hovers in the 70's which i know is high, but from memory i think it doesn't ever get low for some.

GP also explained it, i will ask my Rheumy Nurse on the 23rd when i go for next session for Anti-TNF.

let's hope you are on the right track,

Suzanne x

LynW
#3 Posted : Tuesday, February 15, 2011 8:55:12 PM Quote
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Hi Ailsa

It's just as well I could find my notes! No actually it's imprinted on my brain!

CRP stands for C-Reactive protein and is a test which measures the concentration in blood serum of a special type of protein produced in the liver that is present during episodes of acute inflammation or infection. Normally there is no CRP in blood serum so anything over 10 is indicative of something going on. It is generally thought to be more reliable than the ESR. CRP is more responsive to changes than ESR and the result is therefore usually pretty accurate.

ESR is Erythrocyte Sedimentation Rate (ESR). It is a simple test used to determine how much inflammation is in the body. An ESR test simply notes the speed at which blood cells sink to the bottom of a test tube. The faster the blood cells fall, the more inflammation is in your body. Normal ESR is between 1-7mm but this increases with age and individuals. For some 20-30mm may be quite normal. Mine is generally okay when it's around 16mm. It isn't the most reliable of tests as it can be very slow to react to changes.

Your results are odd ... sorry Ailsa. Are you sero-negative by any chance? It sounds as though the ESR is a rogue result. This can happen, either in the sample taken (it might have started to coagulate ie not shaken well enough) or in the lab (who knows what goes on?!)

In my opinion that CRP result after only 3 injections is brilliant! Long may it continue. I'm sure that if you are feeling better and the inflammation has eased up you are on the right track. I wouldn't worry about ESR ... mine rarely reflects what it's supposed to!! It was over 100 for 6 months (my CRP was 1), I had all sorts of tests but nothing was found! Then it dropped as fast as it had risen and we are none the wiserBlink Ahh such is life!

Lyn x
My son, Ian, completed the BUPA Great North Run on 15th September running for the National Rheumatoid Arthritis Society (NRAS). You can read his story at http://www.justgiving.com/ianlukewilson

Ailsa-H
#4 Posted : Tuesday, February 15, 2011 9:27:22 PM Quote
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Thanks Lyn! I'm not sero-negative. Yep, CRP was 14 and now 7 and I do feel a difference in aches and speed of movement. My ESR has been down in 30s and up in the hundreds but when I',m feeling ok it is generally 40ish. Oh well ... I will resign myself to being odd and be glad I'm feeling a bit better already! Thankyou BigGrin

Good luck for next eek Suzanne. If it's anything like my 2nd anti-TNF appointment, it was just a formality and going through the various drugs. XX Ailsa
posie
#5 Posted : Tuesday, February 15, 2011 11:31:44 PM Quote
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could somebody explain to me what sero-negative means please and thanks
LynW
#6 Posted : Wednesday, February 16, 2011 9:16:45 AM Quote
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Hi Posie

Rheumatoid Arthritis can be diagnosed as sero-positive or sero-negative. Rheumatoid Factor, RF, is an antibody found in blood serum and is helpful in the diagnosis procedure along with inflammation levels and other symptoms.. RF can be positive without a diagnosis of RA but may reflect other auto-immune activity. Likewise a negative result does not rule out RA. RF cannot be used as a tool on its own for diagnosis but the test is often done with the initial blood tests.

I was diagnosed with severe sero-negative RA 23 years ago. There has never been any doubt that I have the disease! Unfortunately my blood results, as with other sero-negative patients, cannot always be relied upon, making disease control a difficult one for the physicians involved.

Hope this helps ... if not, please shout and I'll try and do better!

Lyn x
My son, Ian, completed the BUPA Great North Run on 15th September running for the National Rheumatoid Arthritis Society (NRAS). You can read his story at http://www.justgiving.com/ianlukewilson

posie
#7 Posted : Thursday, February 17, 2011 7:01:12 PM Quote
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LynW wrote:
Hi Posie

Rheumatoid Arthritis can be diagnosed as sero-positive or sero-negative. Rheumatoid Factor, RF, is an antibody found in blood serum and is helpful in the diagnosis procedure along with inflammation levels and other symptoms.. RF can be positive without a diagnosis of RA but may reflect other auto-immune activity. Likewise a negative result does not rule out RA. RF cannot be used as a tool on its own for diagnosis but the test is often done with the initial blood tests.

I was diagnosed with severe sero-negative RA 23 years ago. There has never been any doubt that I have the disease! Unfortunately my blood results, as with other sero-negative patients, cannot always be relied upon, making disease control a difficult one for the physicians involved.

Hope this helps ... if not, please shout and I'll try and do better!

Lyn x

Thanks Lyn i was diagonsed sero negative in june 09 i am now on metx 20 mg a week i must say i have alot less pain from i started them but not completly pain free i have been on 20mg of metx for 4 months do you ever be completly pain free
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